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  1. Acumed LLC
  2. Allergan, Inc.
  3. AlloSource
  4. Altima Partners LLP
  5. Anika Therapeutics, Inc.
  6. Aperion Biologics Corporation
  7. Arrowhead Research Corporation
  8. Arthrex, Inc.
  9. ArthroCare Corporation
  10. Arthro Kinetics Biotechnology GmbH
  11. Artimplant AB
  12. Astellas Pharma, Inc.
  13. Biocomposites LTD
  14. BioMed Ventures/BioMed Realty Trust, Inc.
  15. Biomet, Inc.
  16. BioMimetic Therapeutics, Inc./Wright Medical Group, Inc.
  17. BioSet, Inc.
  18. BioTime, Inc.
  19. BioTissue Technologies GmbH
  20. Bioventus LLC
  21. Boston Millennia Partners
  22. B. Braun Melsungen AG
  23. Calosyn Pharma, Inc.
  24. Carbylan Biosurgery, Inc.
  25. Carticept Medical, Inc.
  26. Cartiva, Inc.
  27. Collagen Matrix, Inc.
  28. ConMed Corporation
  29. ConMed Linvatec
  30. Covidien PLC
  31. CryoLife, Inc.
  32. Cytex Therapeutics, Inc.
  33. DePuy Mitek, Inc./DePuy Synthes, Inc./Johnson & Johnson
  34. EMD Serono, Inc./Merck KGaA
  35. Ferring Pharmaceuticals, Inc.
  36. Fidia Pharma USA, Inc./Fidia Farmaceutici SpA
  37. FinTech GIMV Fund LP/BASF Group
  38. Flex Biomedical, Inc.
  39. Foundation Medical Partners, Inc.
  40. Galderma SA
  41. Geistlich Pharma AG
  42. Genzyme Corporation/Sanofi SA
  43. Geron Corporation
  44. Harvest Technologies Corporation/Terumo Corporation
  45. Histogenics Corporation
  46. Inflection Point Capital LLC
  47. Inion LTD
  48. Integra LifeSciences Corporation
  49. Interpace BioPharma LLC/PDI, Inc.
  50. ISTO Technologies, Inc.
  51. Ivy Sports Medicine LLC
  52. Kensey Nash Corporation/Royal DSM NV
  53. Kinetic Concepts, Inc.
  54. Kolon Life Science, Inc.
  55. LifeCell Corporation
  56. LifeLink Tissue Bank/LifeLink Foundation
  57. LifeNet Health, Inc.
  58. Mandaco 569 LTD
  59. Medipost Co. LTD
  60. Medtronic, Inc.
  61. Mesoblast LTD
  62. MiMedx, Inc.
  63. Musculoskeletal Transplant Foundation, Inc.
  64. Nanotope, Inc./Arrowhead Research Corporation
  65. NovaBone Products LLC
  66. Olympus Biotech Corporation/Olympus Corporation
  67. Organogenesis, Inc.
  68. Orteq LTD
  69. Orthocell Pty LTD
  70. Orthox LTD
  71. Osiris Therapeutics, Inc.
  72. Oxford Biomaterials LTD
  73. Pfizer, Inc.
  74. Piramal Healthcare LTD/ Piramal Group
  75. Pluristem Therapeutics, Inc.
  76. ProChon Biotech LTD
  77. Regentis Biomaterials LTD
  78. RTI Biologics, Inc.
  79. Sanofi SA
  80. Savient Pharmaceuticals, Inc.
  81. Scil Technology GmbH/BioNet Holding GmbH
  82. Seikagaku Corporation
  83. Smith & Nephew PLC
  84. Sofinnova Ventures, Inc.
  85. SoftTissue Regeneration, Inc.
  86. Spineology, Inc.
  87. Split Rock Partners LLC
  88. Stryker Corporation
  89. TEI Biosciences, Inc.
  90. Tepha, Inc.
  91. TETEC AG/B. Braun Melsungen AG
  92. TiGenix NV
  93. TissueGene, Inc.
  94. Tornier NV
  95. Wright Medical Technology, Inc./Wright Medical Group, Inc.
  96. Zimmer Holdings, Inc.
Market Reports


U.S. MARKETS FOR ORTHOPEDIC BIOMATERIALS FOR VISCOSUPPLEMENTATION AND CARTILAGE, LIGAMENT/TENDON, AND MENISCAL REPAIR AND REGENERATION


231 Pages | 66 Exhibits | 2013 Analysis | Forecasts Through 2017




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In the United States (U.S.), aging baby boomers are causing an increase in the prevalence of osteoarthritis and other degenerative joint disorders. In addition, the large and growing Millennial generation is contributing to an increasing number of sports-related injuries.

This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration. This market, as covered by the scope of this report, comprises bioresorbable fixation devices (pins, screws, tacks, and suture anchors), cartilage repair and regeneration technologies (cell-based approaches, cell-free scaffolds, and gene therapy), ligament and tendon repair/replacement/ regeneration products (traditional sports medicine allografts and gene and cell-based therapies, platelet-rich plasma, scaffolds, and synthetic growth factors), meniscal repair/regeneration/replacement technologies (allografts, bioresorbable fixation devices, and scaffolding and cell therapy technologies), and viscosupplementation products (hyaluronic acid-based therapies). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration is projected to reach an estimated value of $1.9 billion in the year 2017.

This is the second of two reports covering the U.S. market for orthopedic biomaterials. Report #A321, "U.S. Markets for Orthopedic Biomaterials for Bone Repair and Regeneration," has also published.





EXECUTIVE SUMMARY

i. Bioresorbable Fixation Devices 
ii. Viscosupplementation 
iii. Cartilage Repair and Regeneration 
iv. Meniscal Repair, Regeneration, and Replacement 
	a. Bioresorbable Fixation Devices 
	b. Meniscal Allografts
v. Ligament and Tendon Repair, Regeneration, and Replacement 
vi. Combined Market Forecast 
vii. Methodology 

Exhibit ES-1: Types of Bioresorbable Fixation Devices 
Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 
Exhibit ES-3: Viscosupplementation Products, Market Forecast, 2012-2017 
Exhibit ES-4: Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017 
Exhibit ES-5: Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017 
Exhibit ES-6: Ligament and Tendon Allografts, Market Forecast, 2012-2017 
Exhibit ES-7: Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration, Combined Market Forecast, 2012-2017 

1. MUSCULOSKELETAL SYSTEM OVERVIEW

1.1 Bone Structure and Function 
	1.1.1 Cellular Framework 
		1.1.1.1 Osteoblasts 
		1.1.1.2 Osteocytes 
		1.1.1.3 Osteoclasts 
		1.1.1.4 Osteogenesis 
	1.1.2 Bone Tissue 
		1.1.2.1 Cancellous and Cortical Bone Tissue 
		1.1.2.2 Bone Marrow 
	1.1.3 Bone Anatomy 
		1.1.3.1 Diaphysis and Epiphysis 
		1.1.3.2 Endosteum 
		1.1.3.3 Periosteum 
	1.1.4 Joint Components 
		1.1.4.1 Cartilage 
			1.1.4.1.1 Elastic Cartilage 
			1.1.4.1.2 Fibrocartilage 
			1.1.4.1.3 Hyaline Cartilage 
		1.1.4.2 Bursae 
		1.1.4.3 Joint Cavity 
		1.1.4.4 Menisci 
		1.1.4.5 Synovial Membrane and Fluid 
		1.1.4.6 Ligaments and Tendons 
		1.1.4.7 Muscles 
	1.1.5 Joint Structures 
		1.1.5.1 Ankle 
		1.1.5.2 Digits 
		1.1.5.3 Elbow 
		1.1.5.4 Hip 
		1.1.5.5 Knee 
		1.1.5.6 Shoulder 
		1.1.5.7 Wrist 
	1.1.6 Bone Formation and Remodeling 
		1.1.6.1 In the Fetus 
		1.1.6.2 In Childhood 
		1.1.6.3 In Adulthood 
		1.1.6.4 In Old Age 
		1.1.6.5 Mechanical Stress and Wolff's Law 
	1.1.7 Factors Affecting Bone Physiology 
		1.1.7.1 Age 
		1.1.7.2 Gender 
		1.1.7.3 Genetic Disposition 
		1.1.7.4 Hormonal Activity 
		1.1.7.5 Physical Activity 
		1.1.7.6 Cigarette Smoking 
		1.1.7.7 Alcohol and Caffeine Intake 
		1.1.7.8 Nutritional Deficiencies 
1.2 Joint Structure and Function 
	1.2.1 Types of Joints 
		1.2.1.1 Synarthroses 
		1.2.1.2 Amphiarthroses 
		1.2.1.3 Diarthroses 
			1.2.1.3.1 Ball-and-Socket 
			1.2.1.3.2 Condyloid 
			1.2.1.3.3 Hinge 
			1.2.1.3.4 Gliding 
			1.2.1.3.5 Pivot 
	1.2.2 Arthritis 
		1.2.2.1 Osteoarthritis 
		1.2.2.2 Rheumatoid Arthritis 
1.3 Management of Joint Disorders 
	1.3.1 Joint Replacement 
		1.3.1.1 Dislocation 
		1.3.1.2 Ligament and Tendon Injuries 
		1.3.1.3 Meniscal Injuries 

Exhibit 1-1: Illustration of Bone Tissue 
Exhibit 1-2: Types of Cartilage 
Exhibit 1-3: Stages of Bone Remodeling 

2. BIORESORBABLE FIXATION DEVICES

2.1 Materials 
2.2 Products 
	2.2.1 Bioresorbable Pins 
	2.2.2 Bioresorbable Screws, Nails, and Tacks 
	2.2.3 Bioresorbable Interference Screws 
	2.2.4 Bioresorbable Suture Anchors 
	2.2.5 Bioresorbable Meniscal Repair Devices 
2.3 Market Analysis 
2.4 Competitive Analysis 

Exhibit 2-1: Advantages of Bioresorbable Fixation Devices 
Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers 
Exhibit 2-3: Types of Bioresorbable Fixation Devices 
Exhibit 2-4: 2013, Selected Bioresorbable Pins 
Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks 
Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws 
Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors 
Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices 
Exhibit 2-9: Bioresorbable Fixation Devices,  Market Forecast, 2012-2017 
Exhibit 2-10: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 

3. VISCOSUPPLEMENTATION

3.1 Osteoarthritis Clinical Overview 
3.2 Viscosupplementation Therapy 
3.3 Products 
	3.3.1 Anika Therapeutics 
	3.3.2 Ferring Pharmaceuticals 
	3.3.3 Fidia Pharma USA/Fidia Farmaceutici 
	3.3.4 Genzyme/Sanofi 
	3.3.5 Seikagaku 
	3.3.6 Smith & Nephew 
3.4 Emerging Products 
3.5 Potential Viscosupplementation Patients 
3.6 Product Reimbursement 
3.7 Market Analysis 
3.8 Competitive Analysis 

Exhibit 3-1: 2013, Administerers of Hyaluronic Acid Injection Therapy,  by Specialty 
Exhibit 3-2: 2013, Selected Viscosupplementation Products 
Exhibit 3-3: 2013, Selected Emerging Viscosupplementation Therapies 
Exhibit 3-4: 2012, Patients with Knee Osteoarthritis 
Exhibit 3-5: Projected Incidence of Symptomatic Knee Osteoarthritis, by 10-Year Age Group 
Exhibit 3-6: Historical and Future Annual Growth Rates in the Elderly Population 
Exhibit 3-7: Viscosupplementation Products, Market Forecast, 2012-2017 
Exhibit 3-8: 2012, Viscosupplementation Products Market, Share by Supplier 

4. CARTILAGE REPAIR AND REGENERATION

4.1 Clinical Overview 
4.2 Products 
	4.2.1 Cell-Based Approaches 
		4.2.1.1 Chondrocyte Transplantation 
			4.2.1.1.1 Anika Therapeutics 
			4.2.1.1.2 BioTissue Technologies 
			4.2.1.1.3 DePuy Mitek/Johnson & Johnson 
			4.2.1.1.4 Geistlich Pharma 
			4.2.1.1.5 Genzyme/Sanofi 
			4.2.1.1.6 ProChon Biotech/Histogenics 
			4.2.1.1.7 Sanofi 
			4.2.1.1.8 TETEC/B. Braun Melsungen 
			4.2.1.1.9 TiGenix 
			4.2.1.1.10 Allogeneic JuvenileChondrocytes 
		4.2.1.2 Stem Cells 
			4.2.1.2.1 Geron 
			4.2.1.2.2 Medipost 
			4.2.1.2.3 Mesoblast 
			4.2.1.2.4 Smith & Nephew 
		4.2.1.3 Growth Factor Technology 
			4.2.1.3.1 BioMimetic Therapeutics/Wright Medical Group 
			4.2.1.3.2 EMD Serono/Merck 
			4.2.1.3.3 Sanofi 
			4.2.1.3.4 TissueGene 
	4.2.2 Cell-Free Composites and Scaffolds 
		4.2.2.1 Anika Therapeutics 
		4.2.2.2 Arthro Kinetics 
		4.2.2.3 Biomet 
		4.2.2.4 BioTissue 
		4.2.2.5 Cartiva 
		4.2.2.6 Cytex 
		4.2.2.7 Histogenics 
		4.2.2.8 Kensey Nash/Royal DSM 
		4.2.2.9 Piramal Healthcare 
		4.2.2.10 Regentis Biomaterials 
		4.2.2.11 Smith & Nephew 
4.3 Reimbursement 
4.4 Market Analysis 
4.5 Competitive Analysis 

Exhibit 4-1: The Outerbridge Classification System for Chondral Defects 
Exhibit 4-2: Arthroscopic Knee Surgery, Procedure Volumes Forecast, 2012-2017 
Exhibit 4-3: 2012, Cartilage Repair Procedures 
Exhibit 4-4: Genzyme's Carticel Autologous Chondrocyte Implantation Device 
Exhibit 4-5: 2013, Selected Chondrocyte Graft Products and Technologies 
Exhibit 4-6: 2013, Selected Emerging Stem Cell-Based Products for Cartilage Repair 
Exhibit 4-7: 2013, Selected Emerging Recombinant Human Growth Factor Products 
Exhibit 4-8: 2013, Selected Cell-Free Scaffolds for Cartilage Repair and Regeneration 
Exhibit 4-9: Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017 
Exhibit 4-10: Cartilage Regeneration, Potential Procedure Volumes Forecast, 2012-2017 

5. MENISCAL REPAIR, REGENERATION, AND REPLACEMENT

5.1 Clinical Overview 
	5.1.1 Meniscal Injuries 
		5.1.1.1 Traumatic Tears 
		5.1.1.2 Degenerative Tears 
5.2 Current Treatment 
	5.2.1 Nonoperative Treatment 
	5.2.2 Surgical Treatment 
		5.2.2.1 Arthroscopic Suturing 
		5.2.2.2 Bioresorbable Fixation 
		5.2.2.3 Meniscectomy 
5.3 Procedure Volumes 
5.4 Meniscal Repair and Regeneration 
	5.4.1 Bioresorbable Fixation Products 
	5.4.2 Market Analysis 
	5.4.3 Competitive Analysis 
5.5 Meniscal Replacement 
	5.5.1 Meniscal Allografts 
	5.5.2 Market Analysis 
	5.5.3 Competitive Analysis 
5.6 Meniscal Repair, Regeneration, and Replacement Technologies  Under Development 
	5.6.1 Scaffolding Technologies 
		5.6.1.1 Collagen 
		5.6.1.2 Fibrin 
		5.6.1.3 Polymers 
	5.6.2 Cell Therapy 
5.7 Combined Market Forecast 

Exhibit 5-1: Anatomy of the Knee Joint 
Exhibit 5-2: Common Types of Meniscal Tears 
Exhibit 5-3: Illustration of a Meniscal Tear 
Exhibit 5-4: Comparison of Treatment Options for Meniscal Injuries 
Exhibit 5-5: Meniscectomy and Meniscal Repair, Procedure Volumes Forecast, 2012-2017 
Exhibit 5-6: 2013, Selected Bioresorbable Fixation Devices for Meniscal Repair 
Exhibit 5-7: Bioresorbable Fixation Devices for Meniscal Repair, Market Forecast, 2012-2017 
Exhibit 5-8: 2012, Market for Bioresorbable Fixation Devices for Meniscal Repair, Share by Supplier 
Exhibit 5-9: 2013, Selected Meniscal Allografts 
Exhibit 5-10: Meniscal Allografts, Market Forecast, 2012-2017 
Exhibit 5-11: 2012, Meniscal Allografts Products Market, Share by Supplier 
Exhibit 5-12: 2013, Selected Meniscal Scaffolding Products Under Development 
Exhibit 5-13: Chondrogen Phase I/II Clinical Trial Results 
Exhibit 5-14: Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017 

6. LIGAMENT AND TENDON REPAIR, REGENERATION, AND REPLACEMENT

6.1 Clinical Overview 
	6.1.1 The Knee 
	6.1.2 The Achilles Tendon 
	6.1.3 Hand Ligaments and Tendons 
	6.1.4 Shoulder Ligaments and Tendons 
6.2 Procedure Volumes 
6.3 Current Treatments 
	6.3.1 Anterior Cruciate Ligament Tears 
	6.3.2 Rotator Cuff Tears 
6.4 Allografts 
6.5 Tissue Engineering 
	6.5.1 Biologic Scaffolds 
	6.5.2 Polymer-Based Scaffolds 
6.6 Growth Factors 
	6.6.1 Platelet-Rich Plasma 
	6.6.2 Synthetic Growth Factors 
6.7 Cell and Gene Therapies 
	6.7.1 Cell-Based Therapies Under Development 
6.8 Market Analysis 
6.9 Competitive Analysis 
6.10 Ligament and Tendon Replacement Market Status 
6.11 Emerging Ligament and Tendon Regeneration Products Market 

Exhibit 6-1: Anatomy of the Knee Joint 
Exhibit 6-2: Anterior Cruciate Ligament Injury 
Exhibit 6-3: Achilles Tendon Rupture 
Exhibit 6-4: Ligaments of the Shoulder 
Exhibit 6-5: 2012, Ligament and Tendon Procedures, by Anatomic Location 
Exhibit 6-6: 2013, Selected Allografts for Ligament and Tendon Replacement 
Exhibit 6-7: 2013, Selected Tissue-Engineered Ligament and Tendon Repair Products 
Exhibit 6-8: 2013, Selected Collagen-Based Scaffolds Under Development for Ligament and Tendon Repair 
Exhibit 6-9: 2013, Selected Synthetic Scaffolds Under Development for Ligament and Tendon Repair 
Exhibit 6-10: Aperion Biologics' Z-Lig Xenograft 
Exhibit 6-11: 2013, Selected Growth Factor Products and Technologies Under Development 
Exhibit 6-12: 2013, Selected Cell-Based Therapy Approaches Under Development for Tendon Repair 
Exhibit 6-13: Ligament and Tendon Allografts, Market Forecast, 2012-2017 
Exhibit 6-14: 2012, Ligament and Tendon Allografts Market, Share by Supplier 

7. COMPANY PROFILES

7.1 Arthrex, Inc. 
7.2 ConMed Linvatec/ConMed Corporation 
7.3 Fidia Pharma USA, Inc./Fidia Farmaceutici SpA 
7.4 Genzyme Corporation/Sanofi SA 
7.5 Johnson & Johnson 
7.6 LifeNet Health, Inc. 
7.7 Medtronic, Inc. 
7.8 Musculoskeletal Transplant Foundation, Inc. 
7.9 RTI Biologics, Inc. 
7.10 Smith & Nephew PLC 

APPENDIX:  COMPANY LISTING
Published by Medtech Insight and distributed exclusively by LSI



This report is listed in the following markets:
Biomaterials, Biotechnology, Orthopedics and Surgery