U.S. MARKETS FOR ORTHOPEDIC BIOMATERIALS FOR VISCOSUPPLEMENTATION AND CARTILAGE, LIGAMENT/TENDON, AND MENISCAL REPAIR AND REGENERATION
231 Pages | 66 Exhibits | 2013 Analysis | Forecasts Through 2017
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In the United States (U.S.), aging baby boomers are causing an increase in the prevalence of osteoarthritis and other degenerative joint disorders. In addition, the large and growing Millennial generation is contributing to an increasing number of sports-related injuries.
This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration. This market, as covered by the scope of this report, comprises bioresorbable fixation devices (pins, screws, tacks, and suture anchors), cartilage repair and regeneration technologies (cell-based approaches, cell-free scaffolds, and gene therapy), ligament and tendon repair/replacement/ regeneration products (traditional sports medicine allografts and gene and cell-based therapies, platelet-rich plasma, scaffolds, and synthetic growth factors), meniscal repair/regeneration/replacement technologies (allografts, bioresorbable fixation devices, and scaffolding and cell therapy technologies), and viscosupplementation products (hyaluronic acid-based therapies). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration is projected to reach an estimated value of $1.9 billion in the year 2017.
This is the second of two reports covering the U.S. market for orthopedic biomaterials. Report #A321, "U.S. Markets for Orthopedic Biomaterials for Bone Repair and Regeneration," has also published.
EXECUTIVE SUMMARY i. Bioresorbable Fixation Devices ii. Viscosupplementation iii. Cartilage Repair and Regeneration iv. Meniscal Repair, Regeneration, and Replacement a. Bioresorbable Fixation Devices b. Meniscal Allografts v. Ligament and Tendon Repair, Regeneration, and Replacement vi. Combined Market Forecast vii. Methodology Exhibit ES-1: Types of Bioresorbable Fixation Devices Exhibit ES-2: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit ES-3: Viscosupplementation Products, Market Forecast, 2012-2017 Exhibit ES-4: Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017 Exhibit ES-5: Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017 Exhibit ES-6: Ligament and Tendon Allografts, Market Forecast, 2012-2017 Exhibit ES-7: Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration, Combined Market Forecast, 2012-2017 1. MUSCULOSKELETAL SYSTEM OVERVIEW 1.1 Bone Structure and Function 1.1.1 Cellular Framework 126.96.36.199 Osteoblasts 188.8.131.52 Osteocytes 184.108.40.206 Osteoclasts 220.127.116.11 Osteogenesis 1.1.2 Bone Tissue 18.104.22.168 Cancellous and Cortical Bone Tissue 22.214.171.124 Bone Marrow 1.1.3 Bone Anatomy 126.96.36.199 Diaphysis and Epiphysis 188.8.131.52 Endosteum 184.108.40.206 Periosteum 1.1.4 Joint Components 220.127.116.11 Cartilage 18.104.22.168.1 Elastic Cartilage 22.214.171.124.2 Fibrocartilage 126.96.36.199.3 Hyaline Cartilage 188.8.131.52 Bursae 184.108.40.206 Joint Cavity 220.127.116.11 Menisci 18.104.22.168 Synovial Membrane and Fluid 22.214.171.124 Ligaments and Tendons 126.96.36.199 Muscles 1.1.5 Joint Structures 188.8.131.52 Ankle 184.108.40.206 Digits 220.127.116.11 Elbow 18.104.22.168 Hip 22.214.171.124 Knee 126.96.36.199 Shoulder 188.8.131.52 Wrist 1.1.6 Bone Formation and Remodeling 184.108.40.206 In the Fetus 220.127.116.11 In Childhood 18.104.22.168 In Adulthood 22.214.171.124 In Old Age 126.96.36.199 Mechanical Stress and Wolff's Law 1.1.7 Factors Affecting Bone Physiology 188.8.131.52 Age 184.108.40.206 Gender 220.127.116.11 Genetic Disposition 18.104.22.168 Hormonal Activity 22.214.171.124 Physical Activity 126.96.36.199 Cigarette Smoking 188.8.131.52 Alcohol and Caffeine Intake 184.108.40.206 Nutritional Deficiencies 1.2 Joint Structure and Function 1.2.1 Types of Joints 220.127.116.11 Synarthroses 18.104.22.168 Amphiarthroses 22.214.171.124 Diarthroses 126.96.36.199.1 Ball-and-Socket 188.8.131.52.2 Condyloid 184.108.40.206.3 Hinge 220.127.116.11.4 Gliding 18.104.22.168.5 Pivot 1.2.2 Arthritis 22.214.171.124 Osteoarthritis 126.96.36.199 Rheumatoid Arthritis 1.3 Management of Joint Disorders 1.3.1 Joint Replacement 188.8.131.52 Dislocation 184.108.40.206 Ligament and Tendon Injuries 220.127.116.11 Meniscal Injuries Exhibit 1-1: Illustration of Bone Tissue Exhibit 1-2: Types of Cartilage Exhibit 1-3: Stages of Bone Remodeling 2. BIORESORBABLE FIXATION DEVICES 2.1 Materials 2.2 Products 2.2.1 Bioresorbable Pins 2.2.2 Bioresorbable Screws, Nails, and Tacks 2.2.3 Bioresorbable Interference Screws 2.2.4 Bioresorbable Suture Anchors 2.2.5 Bioresorbable Meniscal Repair Devices 2.3 Market Analysis 2.4 Competitive Analysis Exhibit 2-1: Advantages of Bioresorbable Fixation Devices Exhibit 2-2: Factors Affecting the Properties of Bioresorbable Polymers Exhibit 2-3: Types of Bioresorbable Fixation Devices Exhibit 2-4: 2013, Selected Bioresorbable Pins Exhibit 2-5: 2013, Selected Bioresorbable Nails, Screws, and Tacks Exhibit 2-6: 2013, Selected Bioresorbable Interference Screws Exhibit 2-7: 2013, Selected Bioresorbable Suture Anchors Exhibit 2-8: 2013, Selected Bioresorbable Meniscal Repair Devices Exhibit 2-9: Bioresorbable Fixation Devices, Market Forecast, 2012-2017 Exhibit 2-10: 2012, Bioresorbable Fixation Devices Market, Share by Supplier 3. VISCOSUPPLEMENTATION 3.1 Osteoarthritis Clinical Overview 3.2 Viscosupplementation Therapy 3.3 Products 3.3.1 Anika Therapeutics 3.3.2 Ferring Pharmaceuticals 3.3.3 Fidia Pharma USA/Fidia Farmaceutici 3.3.4 Genzyme/Sanofi 3.3.5 Seikagaku 3.3.6 Smith & Nephew 3.4 Emerging Products 3.5 Potential Viscosupplementation Patients 3.6 Product Reimbursement 3.7 Market Analysis 3.8 Competitive Analysis Exhibit 3-1: 2013, Administerers of Hyaluronic Acid Injection Therapy, by Specialty Exhibit 3-2: 2013, Selected Viscosupplementation Products Exhibit 3-3: 2013, Selected Emerging Viscosupplementation Therapies Exhibit 3-4: 2012, Patients with Knee Osteoarthritis Exhibit 3-5: Projected Incidence of Symptomatic Knee Osteoarthritis, by 10-Year Age Group Exhibit 3-6: Historical and Future Annual Growth Rates in the Elderly Population Exhibit 3-7: Viscosupplementation Products, Market Forecast, 2012-2017 Exhibit 3-8: 2012, Viscosupplementation Products Market, Share by Supplier 4. CARTILAGE REPAIR AND REGENERATION 4.1 Clinical Overview 4.2 Products 4.2.1 Cell-Based Approaches 18.104.22.168 Chondrocyte Transplantation 22.214.171.124.1 Anika Therapeutics 126.96.36.199.2 BioTissue Technologies 188.8.131.52.3 DePuy Mitek/Johnson & Johnson 184.108.40.206.4 Geistlich Pharma 220.127.116.11.5 Genzyme/Sanofi 18.104.22.168.6 ProChon Biotech/Histogenics 22.214.171.124.7 Sanofi 126.96.36.199.8 TETEC/B. Braun Melsungen 188.8.131.52.9 TiGenix 184.108.40.206.10 Allogeneic JuvenileChondrocytes 220.127.116.11 Stem Cells 18.104.22.168.1 Geron 22.214.171.124.2 Medipost 126.96.36.199.3 Mesoblast 188.8.131.52.4 Smith & Nephew 184.108.40.206 Growth Factor Technology 220.127.116.11.1 BioMimetic Therapeutics/Wright Medical Group 18.104.22.168.2 EMD Serono/Merck 22.214.171.124.3 Sanofi 126.96.36.199.4 TissueGene 4.2.2 Cell-Free Composites and Scaffolds 188.8.131.52 Anika Therapeutics 184.108.40.206 Arthro Kinetics 220.127.116.11 Biomet 18.104.22.168 BioTissue 22.214.171.124 Cartiva 126.96.36.199 Cytex 188.8.131.52 Histogenics 184.108.40.206 Kensey Nash/Royal DSM 220.127.116.11 Piramal Healthcare 18.104.22.168 Regentis Biomaterials 22.214.171.124 Smith & Nephew 4.3 Reimbursement 4.4 Market Analysis 4.5 Competitive Analysis Exhibit 4-1: The Outerbridge Classification System for Chondral Defects Exhibit 4-2: Arthroscopic Knee Surgery, Procedure Volumes Forecast, 2012-2017 Exhibit 4-3: 2012, Cartilage Repair Procedures Exhibit 4-4: Genzyme's Carticel Autologous Chondrocyte Implantation Device Exhibit 4-5: 2013, Selected Chondrocyte Graft Products and Technologies Exhibit 4-6: 2013, Selected Emerging Stem Cell-Based Products for Cartilage Repair Exhibit 4-7: 2013, Selected Emerging Recombinant Human Growth Factor Products Exhibit 4-8: 2013, Selected Cell-Free Scaffolds for Cartilage Repair and Regeneration Exhibit 4-9: Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017 Exhibit 4-10: Cartilage Regeneration, Potential Procedure Volumes Forecast, 2012-2017 5. MENISCAL REPAIR, REGENERATION, AND REPLACEMENT 5.1 Clinical Overview 5.1.1 Meniscal Injuries 126.96.36.199 Traumatic Tears 188.8.131.52 Degenerative Tears 5.2 Current Treatment 5.2.1 Nonoperative Treatment 5.2.2 Surgical Treatment 184.108.40.206 Arthroscopic Suturing 220.127.116.11 Bioresorbable Fixation 18.104.22.168 Meniscectomy 5.3 Procedure Volumes 5.4 Meniscal Repair and Regeneration 5.4.1 Bioresorbable Fixation Products 5.4.2 Market Analysis 5.4.3 Competitive Analysis 5.5 Meniscal Replacement 5.5.1 Meniscal Allografts 5.5.2 Market Analysis 5.5.3 Competitive Analysis 5.6 Meniscal Repair, Regeneration, and Replacement Technologies Under Development 5.6.1 Scaffolding Technologies 22.214.171.124 Collagen 126.96.36.199 Fibrin 188.8.131.52 Polymers 5.6.2 Cell Therapy 5.7 Combined Market Forecast Exhibit 5-1: Anatomy of the Knee Joint Exhibit 5-2: Common Types of Meniscal Tears Exhibit 5-3: Illustration of a Meniscal Tear Exhibit 5-4: Comparison of Treatment Options for Meniscal Injuries Exhibit 5-5: Meniscectomy and Meniscal Repair, Procedure Volumes Forecast, 2012-2017 Exhibit 5-6: 2013, Selected Bioresorbable Fixation Devices for Meniscal Repair Exhibit 5-7: Bioresorbable Fixation Devices for Meniscal Repair, Market Forecast, 2012-2017 Exhibit 5-8: 2012, Market for Bioresorbable Fixation Devices for Meniscal Repair, Share by Supplier Exhibit 5-9: 2013, Selected Meniscal Allografts Exhibit 5-10: Meniscal Allografts, Market Forecast, 2012-2017 Exhibit 5-11: 2012, Meniscal Allografts Products Market, Share by Supplier Exhibit 5-12: 2013, Selected Meniscal Scaffolding Products Under Development Exhibit 5-13: Chondrogen Phase I/II Clinical Trial Results Exhibit 5-14: Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017 6. LIGAMENT AND TENDON REPAIR, REGENERATION, AND REPLACEMENT 6.1 Clinical Overview 6.1.1 The Knee 6.1.2 The Achilles Tendon 6.1.3 Hand Ligaments and Tendons 6.1.4 Shoulder Ligaments and Tendons 6.2 Procedure Volumes 6.3 Current Treatments 6.3.1 Anterior Cruciate Ligament Tears 6.3.2 Rotator Cuff Tears 6.4 Allografts 6.5 Tissue Engineering 6.5.1 Biologic Scaffolds 6.5.2 Polymer-Based Scaffolds 6.6 Growth Factors 6.6.1 Platelet-Rich Plasma 6.6.2 Synthetic Growth Factors 6.7 Cell and Gene Therapies 6.7.1 Cell-Based Therapies Under Development 6.8 Market Analysis 6.9 Competitive Analysis 6.10 Ligament and Tendon Replacement Market Status 6.11 Emerging Ligament and Tendon Regeneration Products Market Exhibit 6-1: Anatomy of the Knee Joint Exhibit 6-2: Anterior Cruciate Ligament Injury Exhibit 6-3: Achilles Tendon Rupture Exhibit 6-4: Ligaments of the Shoulder Exhibit 6-5: 2012, Ligament and Tendon Procedures, by Anatomic Location Exhibit 6-6: 2013, Selected Allografts for Ligament and Tendon Replacement Exhibit 6-7: 2013, Selected Tissue-Engineered Ligament and Tendon Repair Products Exhibit 6-8: 2013, Selected Collagen-Based Scaffolds Under Development for Ligament and Tendon Repair Exhibit 6-9: 2013, Selected Synthetic Scaffolds Under Development for Ligament and Tendon Repair Exhibit 6-10: Aperion Biologics' Z-Lig Xenograft Exhibit 6-11: 2013, Selected Growth Factor Products and Technologies Under Development Exhibit 6-12: 2013, Selected Cell-Based Therapy Approaches Under Development for Tendon Repair Exhibit 6-13: Ligament and Tendon Allografts, Market Forecast, 2012-2017 Exhibit 6-14: 2012, Ligament and Tendon Allografts Market, Share by Supplier 7. COMPANY PROFILES 7.1 Arthrex, Inc. 7.2 ConMed Linvatec/ConMed Corporation 7.3 Fidia Pharma USA, Inc./Fidia Farmaceutici SpA 7.4 Genzyme Corporation/Sanofi SA 7.5 Johnson & Johnson 7.6 LifeNet Health, Inc. 7.7 Medtronic, Inc. 7.8 Musculoskeletal Transplant Foundation, Inc. 7.9 RTI Biologics, Inc. 7.10 Smith & Nephew PLC APPENDIX: COMPANY LISTING
This report is listed in the following markets:
Biomaterials, Biotechnology, Orthopedics and Surgery